Fittolerance

Check out our Thermal Range Calculator to see how materials will grow and/or shrink when in operation. Contact our on-site engineers for additional assistance.

Machine your shaft and housing unit within the recommended tolerances to achieve the right ball-bearing press fit for your application.

Every application may have specifics that need to be taken into account to adjust a standard system tolerance strategy to unique parameters. Please contact GMN Bearing USA Ltd engineers for technical support and questions.

Includes built-in ball bearing support. Supports MEDIUM loads & low to medium torque capacity: 53 to 267 Nm. Bore (ID) sizes: 17 to 40 mm (0.669 to 1.57 in)

The best protection for your bearing. Easy to install with a simple “drop-in” next to your bearing. No added space needed. CF seals offer 100% sealing efficiency against splashing liquids.

No built-in ball bearing support. Good for large orders & low to high torque needs: 1 to 2673 Nm. Bore (ID) sizes: 2 to 240 mm (0.078 to 9.448 in)

Introduction: Bone growth is accomplished by a dynamic equilibrium between formation by osteoblasts and resorption by osteoclasts, which are regulated by many systemic and local osteotropic factors that induce osteoclast formation from hematopoietic precursors through RANK/RANKL signaling. There are four subtypes of prostaglandin E (PGE) receptors, EP1, EP2, EP3, and EP4, and PGE2 facilitates bone resorption by a mechanism mediated by EP2/EP4. It is well known that SC-19220 is an EP1-specific antagonist. We previously found that SC-19220 inhibited osteoclastogenesis induced by osteotropic factors, including PGE2; however, the inhibitory mechanism is not clear. In this study, we investigated the inhibitory effects of SC-19220 on osteoclastogenesis induced by RANK/RANKL signaling in mouse cell cultures and analyzed the mechanism involved.

Results and conclusion: SC-19220 dose-dependently inhibited osteoclast formation induced by PGE2, 11-deoxy-PGE1, and RANKL in the mouse culture system; however, it had no influence on RANKL expression in osteoblasts induced by PGE2. Furthermore, the expression of RANK and c-Fms in osteoclast precursors was decreased by SC-19220 at the mRNA and protein levels. In RANK signaling networks, SC-19220 inhibited c-Src and NFAT2 expression. Our findings indicated that SC-19220 inhibits RANKL-induced osteoclastogenesis through the suppression of RANK, c-Fms, c-Src, and NFAT2, suggesting that this EP1-specific antagonist inhibits osteoclast formation induced by RANKL from the early stage of osteoclastogenesis.

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H8tolerance

DISCLAIMER: GMN Bearing USA, Ltd. (“GMN”) makes this calculator and other engineering guides, tools and information available on the gmnbt.com website (collectively, the “Tools”) to help engineers save time and design better products. This calculator and the other Tools are provided for information purposes only and are subject to change. Neither this calculator nor any other Tools are intended to offer engineering or technical advice, be a substitute for product design, analysis and selection by engineering professionals, or to serve as an instruction from GMN as to the selection of a particular GMN product. By its use of this calculator, user acknowledges that proper tolerancing is influenced by many factors not accounted for by this calculator including, but not limited to, bearing size, RPM, temperature, materials, and duty cycle. THIS CALCULATOR IS PROVIDED “AS-IS” WITHOUT ANY WARRANTY WHATSOEVER. THE INFORMATION PROVIDED BY THIS CALCULATOR IS PROVIDED FOR THE CONVENIENCE OF USERS, BUT SHOULD NOT BE USED TO SERVE AS AN INSTRUCTION FROM GMN AS TO THE SELECTION OF A PARTICULAR GMN PRODUCT OR AS A SUBSTITUTE FOR PROFESSIONAL ENGINEERING OR TECHNICAL ADVICE. WHILE EFFORTS HAVE BEEN MADE TO MAKE THE INFORMATION PROVIDED BY THE CALCULATOR ACCURATE, GMN DOES NOT WARRANT THE ACCURACY OF THE INFORMATION OBTAINED FROM THE CALCULATOR. USER ASSUMES ALL RISKS AND RESPONSIBILITIES FOR THE USE OF AND RESULTS OBTAINED FROM THE CALCULATOR. GMN MAKES NO WARRANTY THAT THE CALCULATOR WILL BE ERROR FREE OR FREE FROM INTERRUPTION OR FAILURE. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, GMN DISCLAIMS AND EXCLUDES ALL REPRESENTATIONS, WARRANTIES, EITHER EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, AND NONINFRINGEMENT WITH RESPECT TO THE CALCULATOR. USER ACKNOWLEDGES THAT THE CALCULATOR MAY NOT BE AVAILABLE OR MAY BECOME UNAVAILABLE DUE TO ANY NUMBER OF FACTORS. THEREFORE, GMN EXPRESSLY DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY REGARDING SYSTEM AND/OR CALCULATOR AVAILABILITY, ACCESSIBILITY, OR PERFORMANCE.

This heavy-duty clutch (aka a hold-back clutch) is good for high torque operations and ensures motion freezes in place. Bore (ID) sizes: 15 to 40 mm. (0.59 to 1.73 in)

Our GMN Gap Seals are plastic and a great choice for washdown applications, such as food conveyors and food manufacturing facilities

Bearinglookup

The precision bearing system tolerance calculator is to support engineers in the initial stages of their product design. The below bearing, shaft, and housing tolerances are per ABEC / DIN / ISO standards. There is also a built in RPM tolerance adjustment. The RPM adjustment factor is done per GMN internal standards and experience to insure a proper inner race press fit at high RPM’s. Inner race slippage can cause premature bearing failure for a super precision bearing application.

Includes built-in ball bearing support. Supports HEAVY loads & has a high torque capacity: 53 to 588 Nm. Bore (ID) sizes: 10 to 60 mm (0.393 to 2.362 in)

This calculator helps you find the right machined shaft and housing tolerance recommendations to ensure a press fit is achieved. The RPM adjustment factor is based on GMN ball bearing standards and our many years of bearing experience.

DISCLAIMER: The data provided on this page is for general information purposes only. While the intention is to provide accurate information, the calculations performed by this tool are based on publically available information distributed by third parties and assume the accuracy of such information. There is NO WARRANTY OR GUARANTY, expressed or implied, regarding the accuracy of this information or its applicability to your engineering situation.

Bearinghousingtolerance

No built-in ball bearing support. Has no RPM limits & Supports high torque needs: 609 to 14,060 Nm. Bore (ID) sizes: 38.09 to 220 mm (1.499 to 8.66 in)

We know that not every application requires super, high-precision bearings. We stock other industrial parts from quality brands.

Materials and methods: A bone marrow culture system and bone marrow macrophages were used to examine the effects of SC-19220 on PGE2-, 11-deoxy-PGE1-, and RANKL-induced osteoclastogenesis. We analyzed RANKL expression in osteoblasts induced by PGE2 using RT-PCR. We also examined the effects of SC-19220 on the macrophage-colony-stimulating factor (M-CSF) receptor (c-Fms) and RANK expression in osteoclast precursors as well as RANK/RANKL signaling using RT-PCR and Western blotting analyses.

High-speed applications produce a high centrifugal force that causes the inner ring of a bearing to expand. This could cause a press-fit bearing to turn into a bearing slipping on the shaft. If this results, then drastic machine malfunctions could occur. It’s important that the inner ring of the bearing stays pressed into the shaft during operation.

Designed with grooves in the outer ring to offer more protection (than our L-type seal) against contamination and direct spray liquids. Liquid gets pushed out through outer grooves when in rotation.

We examined the direct effect of SC-19220, an EP1 prostaglandin (PG) E2 receptor antagonist, on osteoclastogenesis induced by RANK/RANKL signaling in mouse cell cultures. We found that SC-19220 inhibited RANKL-induced osteoclastogenesis by suppression of the RANK/RANKL signaling pathway in osteoclast precursors.