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Antibody first published in: Nelson et al. Structure-Guided Combinatorial Engineering Facilitates Affinity and Specificity Optimization of Anti-CD81 Antibodies J Mol Biol. 2018 Jul 6;430(14):2139-2152. doi: 10.1016/j.jmb.2018.05.018. Epub 2018 May 17 PMID:29778602 Note on publication: The original publication explores the development of antibodies targeting the host antigen CD81 to block hepatitis C viral entry.

Alternative Name(s) of Target: CD81 antigen; 26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28 (Tspan-28) Immunogen: The original antibody was generated by immunization of Balb/c and Naval Medical Research Institute (NMRI) mice with CD81 extracellular loop 2 (ECL2) protein.

Application Notes: The scFv version of this antibody is based on an anti-CD81 clone whose binding specificity was determined via FACS that was successfully used in an inhibition assay against HCV (Ji et al., 2015; PMID: 25417967). The exact binding site of this antibody was determined via crystallization (Nelson et al., 2018; PMID: 29778602). The scFv version of this antibody was used successfully in FC (Susa et al., 2020; PMID: 32338599).

Recombinant monoclonal antibody to CD81. Manufactured using AbAb’s Recombinant Platform with variable regions (i.e. specificity) from the phage display antibody Ab10.