Other Medicines and Supplements. Prochlorperazine may interact with other medicines and supplements. Before using prochlorperazine, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and only take the next dose. Do not take double or extra doses.

Blood Disorders. Prochlorperazine can cause blood disorders, such as agranulocytosis, low neutrophil levels (neutropenia), and low white blood cell levels (leukopenia). Keep all appointments to have your blood checked. Call your healthcare provider right away if you have any of the following symptoms of blood disorders.

There may be other side effects of prochlorperazine that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.

While less common, the most serious side effects of prochlorperazine are described below, along with what to do if they happen.

Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking. This will help them determine if prochlorperazine is right for you.

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Psychosis Related to Dementia. There is a higher risk of death in older adults who take prochlorperazine or another antipsychotic and have psychosis related to dementia. Prochlorperazine is not approved to treat dementia-related psychosis.

The most common side effects of prochlorperazine are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

If you or someone else has used too much prochlorperazine, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.

Immune System Reactions. Prochlorperazine can cause inflammation of your liver, blood vessels, or lymph vessels, and can cause symptoms that look like a condition called lupus. Stop taking prochlorperazine and call your healthcare provider right away if you develop any of the following symptoms.

Low Blood Pressure Upon Standing (Orthostatic Hypotension) and Falls. Prochlorperazine may cause a sudden drop in blood pressure when standing up. To help prevent this, be careful not to get up too quickly. If you feel faint or dizzy, sit or lie down right away until the dizziness stops, then take your time getting up again. Tell your healthcare provider right away if you have any of the following symptoms of orthostatic hypotension.

Prochlorperazine may cause false-positive results on a pregnancy test. This means the test may say you are pregnant when you are not pregnant. If you have a positive pregnancy test when taking prochlorperazine, talk to your healthcare provider about how to confirm whether or not you are really pregnant.Â

Prochlorperazine can make your skin more sensitive to light from the sun, sunlamps, and tanning beds. This is called photosensitivity. Exposure to this light can cause severe sunburns, blisters, and swelling. If you need to be in sunlight, wear sunscreen, a hat, and clothing that covers your skin.

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Decreased Awareness. Prochlorperazine should not be used by people who are in a coma or who have decreased consciousness.

People 65 and older can be at greater risk for some side effects from prochlorperazine. Talk to your healthcare provider about your risks if you are in this age group.

High Prolactin Level (Hyperprolactinemia). Prochlorperazine may cause an increased level of the hormone prolactin in your blood. Increased levels of prolactin could lead to fertility or bone problems. Contact your healthcare provider if you have any of the following symptoms.

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Parkinson-like Symptoms. Prochlorperazine may cause involuntary movement problems, including shakiness, stiffness, or jerkiness. It can also cause drooling, falling, or walking or balance problems. These are called Parkinson-like symptoms, or parkinsonism. Call your healthcare provider right away if you develop any Parkinson-like symptoms.

Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are taking.

Overview: Prochlorperazine is used to treat schizophrenia, anxiety, or severe nausea and vomiting. It belongs to a group of medicines called first-generation (typical) antipsychotics. Common side effects include blurred vision, constipation, dizziness, and drowsiness. Serious side effects may include uncontrolled movements, blood disorders, and low blood pressure upon standing.

The risk of sleepiness and reduced alertness or concentration may be increased if you drink alcohol while taking prochlorperazine. It is best to limit the amount of alcohol you drink.

Liver Damage. Liver damage, also called hepatotoxicity, can happen when taking prochlorperazine. Call your healthcare provider right away if you have any of the following symptoms of liver damage.

Oral Tablet. Prochlorperazine tablets should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place, in a tight, light-resistant container.

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Do not stop taking prochlorperazine without talking to your healthcare provider. Stopping too quickly may cause serious side effects. Call your healthcare provider right away if you have any of the following symptoms.

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Prochlorperazine is also available in a suppository form that is inserted into the rectum. See Prochlorperazine rectal for more information.

Eye Effects. Prochlorperazine may have effects on your eyes, such as deposits on the cornea and lens. This may be more likely if you take higher doses of prochlorperazine, or if you take prochlorperazine for a longer period of time. Your healthcare provider may recommend that you have your eyes examined regularly while taking prochlorperazine. Tell your healthcare provider right away if you have eye discomfort or changes in your vision.

Pregnancy. It is not known if or how prochlorperazine could affect pregnancy or harm an unborn baby. Taking prochlorperazine during the third trimester of pregnancy could cause a newborn baby to have symptoms such as agitation, breathing problems, or trouble feeding. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take prochlorperazine while you are pregnant or trying to get pregnant.

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Uncontrolled Movements. Prochlorperazine can cause some people to have movements that they cannot control. This condition, called tardive dyskinesia (TD), can cause jerky movements of your face, tongue, or body. TD can be permanent. Call your healthcare provider right away if you have any symptoms of TD.

Restlessness. Prochlorperazine may cause restlessness, jitteriness, agitation, or possibly trouble sleeping. Tell your healthcare provider right away if you have these symptoms.Â

This may not be a complete list of medicines that can interact with prochlorperazine. Always check with your healthcare provider.

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Prochlorperazine belongs to a group of medicines called first-generation (typical) antipsychotics. It blocks some areas in the brain where the natural chemical, dopamine, works. This lowers the effect of dopamine in the body. Dopamine affects your behavior and thinking. Plus, dopamine can trigger vomiting.

Neuroleptic Malignant Syndrome (NMS). Antipsychotic medicines, like prochlorperazine, can cause a rare but serious condition called neuroleptic malignant syndrome. NMS can lead to death. Stop using prochlorperazine and call your healthcare provider right away if you have any of the following symptoms.

Injection Liquid. Injectable prochlorperazine is usually given by a healthcare provider in a hospital or clinic. You will not store it at home.

Certain Children. Prochlorperazine should not be used in certain children, such as those under two years old or who weigh less than 20 pounds.Â

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Severe Allergic Reactions. Prochlorperazine may cause allergic reactions, which can be serious. Stop using prochlorperazine and get help right away if you have any of the following symptoms of a serious allergic reaction.

Breastfeeding. Prochlorperazine passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed.

Prochlorperazine can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how prochlorperazine affects you.