Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop.Khush KK, Bernat JL, Pierson RN 3rd, Silverman HJ, Parent B, Glazier AK, Adams AB, Fishman JA, Gusmano M, Hawthorne WJ, Homan ME, Hurst DJ, Latham S, Park CG, Maschke KJ, Mohiuddin MM, Montgomery RA, Odim J, Pentz RD, Reichart B, Savulescu J, Wolpe PR, Wong RP, Fenton KNAm J Transplant. 2024 Jun;24(6):918-927. doi: 10.1016/j.ajt.2024.03.015. Epub 2024 Mar 19.PMID: 38514013

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James L. Bernat, M.D., formerly the Louis and Ruth Frank Professor of Neuroscience at Dartmouth Medical School, earned a B.A. from the University of Massachusetts (1965-69) and an M.D. from Cornell University Medical College (1969-73). He trained in internal medicine and neurology at the Dartmouth-Hitchcock Medical Center (1973-77). Dr. Bernat has been a Dartmouth Medical School faculty member since 1976 and has held the rank of Professor of Medicine and Neurology since 1989. Dr. Bernat was the Director of the Program in Clinical Ethics at the Dartmouth-Hitchcock Medical Center. Previously he served as Assistant Dean of Clinical Education at Dartmouth Medical School. He served for 28 years on the American Academy of Neurology Ethics, Law & and Humanities Committee, with 10 years as chairman. Dr. Bernat has been elected to Phi Beta Kappa, Alpha Omega Alpha, and fellowships in the American College of Physicians, the American Academy of Neurology, the American Neurological Association, and The Hastings Center. In 2011, he received the Presidential Award from the American Academy of Neurology for lifetime service to American neurology. In 2022, he received the Steven E. Hyman Award for Distinguished Service to the Field of Neuroethics from the International Neuroethics Society. Dr. Bernat's scholarly interests are in ethical and philosophical issues in neurology. He has authored over 300 articles and chapters on topics in neurology and clinical ethics. He is the author of Ethical Issues in Neurology, 3rd ed. (Lippincott Williams & Wilkins, 2008), coeditor of Palliative Care in Neurology (Oxford University Press, 2004), coeditor of Ethical and Legal Issues in Neurology (Elsevier, 2013), and coeditor of Death Determination by Neurologic Criteria: Areas of Controversy and Consensus (Springer, 2022). He testified on the vegetative state before the United States Senate Health Committee and was a consultant on brain death to the Institute of Medicine, the Vatican Pontifical Academy of Sciences, and the Pontifical Academy for Life. He chaired the US DHHS HRSA Division of Transplantation panel on determining death in organ donors, served on the World Health Organization international committee on standards for death determination, and cochaired the 2023 NIH Conference on Circulatory Death Determination.

The Uniform Law Commission and the Conceptual Basis for Brain Death: The UDDA Revision Series.Bernat JLNeurology. 2024 Mar 26;102(6):e209157. doi: 10.1212/WNL.0000000000209157. Epub 2024 Feb 26.PMID: 38408292

Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.Bernat JL, Khush KK, Shemie SD, Hartwig MG, Reese PP, Dalle Ave A, Parent B, Glazier AK, Capron AM, Craig M, Gofton T, Gordon EJ, Healey A, Homan ME, Ladin K, Messer S, Murphy N, Nakagawa TA, Parker WF, Pentz RD, Rodriguez-Arias D, Schwartz B, Sulmasy DP, Truog RD, Wall AE, Wall SP, Wolpe PR, Fenton KNJ Heart Lung Transplant. 2024 Jun;43(6):1021-1029. doi: 10.1016/j.healun.2024.02.1455. Epub 2024 Mar 2.PMID: 38432523

Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Jul;54(4):14-23. doi: 10.1002/hast.1584. Epub 2024 May 20.PMID: 38768312

Adam Omelianchuk, Alexander Morgan Capron, Lainie Friedman Ross, Arthur R. Derse, James L. Bernat, and David Magnus reply.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Sep;54(5):37-38. doi: 10.1002/hast.4920.PMID: 39487773

In Emacs before 29.3, arbitrary Lisp code is evaluated as part of turning on Org mode. This affects Org Mode before 9.6.23.

Adam Omelianchuk, Alexander Morgan Capron, Lainie Friedman Ross, Arthur R. Derse, James L. Bernat, and David Magnus reply.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Sep;54(5):37-38. doi: 10.1002/hast.4920.PMID: 39487773The Unified Brain-Based Determination of Death Conceptually Justifies Death Determination in DCDD and NRP Protocols.Bernat JLAm J Bioeth. 2024 Jun;24(6):4-15. doi: 10.1080/15265161.2024.2337392. Epub 2024 Jun 3.PMID: 38829591Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Jul;54(4):14-23. doi: 10.1002/hast.1584. Epub 2024 May 20.PMID: 38768312Advancing the Scientific Basis for Determining Death in Controlled Organ Donation After Circulatory Determination of Death.Murphy NB, Shemie SD, Capron A, Truog RD, Nakagawa T, Healey A, Gofton T, Bernat JL, Fenton K, Khush KK, Schwartz B, Wall SPTransplantation. 2024 Nov 1;108(11):2197-2208. doi: 10.1097/TP.0000000000005002. Epub 2024 Apr 19.PMID: 38637919Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop.Khush KK, Bernat JL, Pierson RN 3rd, Silverman HJ, Parent B, Glazier AK, Adams AB, Fishman JA, Gusmano M, Hawthorne WJ, Homan ME, Hurst DJ, Latham S, Park CG, Maschke KJ, Mohiuddin MM, Montgomery RA, Odim J, Pentz RD, Reichart B, Savulescu J, Wolpe PR, Wong RP, Fenton KNAm J Transplant. 2024 Jun;24(6):918-927. doi: 10.1016/j.ajt.2024.03.015. Epub 2024 Mar 19.PMID: 38514013Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.Bernat JL, Khush KK, Shemie SD, Hartwig MG, Reese PP, Dalle Ave A, Parent B, Glazier AK, Capron AM, Craig M, Gofton T, Gordon EJ, Healey A, Homan ME, Ladin K, Messer S, Murphy N, Nakagawa TA, Parker WF, Pentz RD, Rodriguez-Arias D, Schwartz B, Sulmasy DP, Truog RD, Wall AE, Wall SP, Wolpe PR, Fenton KNJ Heart Lung Transplant. 2024 Jun;43(6):1021-1029. doi: 10.1016/j.healun.2024.02.1455. Epub 2024 Mar 2.PMID: 38432523The Uniform Law Commission and the Conceptual Basis for Brain Death: The UDDA Revision Series.Bernat JLNeurology. 2024 Mar 26;102(6):e209157. doi: 10.1212/WNL.0000000000209157. Epub 2024 Feb 26.PMID: 38408292Taking the pulse of brain death: A meta-analysis of the natural history of brain death with somatic support.Gambardella I, Nappi F, Worku B, Tranbaugh RF, Ibrahim AM, Balaram SK, Bernat JLEur J Neurol. 2024 May;31(5):e16243. doi: 10.1111/ene.16243. Epub 2024 Feb 20.PMID: 38375732Ethical issues of nosology in disorders of consciousness.Robbins NM, Bernat JLNeuroRehabilitation. 2024;54(1):3-9. doi: 10.3233/NRE-230120.PMID: 38277312The Brainstem Criterion of Death and Accurate Syndromic Diagnosis.Bernat JLAm J Bioeth. 2024 Jan;24(1):100-103. doi: 10.1080/15265161.2023.2278554. Epub 2024 Jan 18.PMID: 38236869View more publications on PubMed

Advancing the Scientific Basis for Determining Death in Controlled Organ Donation After Circulatory Determination of Death.Murphy NB, Shemie SD, Capron A, Truog RD, Nakagawa T, Healey A, Gofton T, Bernat JL, Fenton K, Khush KK, Schwartz B, Wall SPTransplantation. 2024 Nov 1;108(11):2197-2208. doi: 10.1097/TP.0000000000005002. Epub 2024 Apr 19.PMID: 38637919

The Brainstem Criterion of Death and Accurate Syndromic Diagnosis.Bernat JLAm J Bioeth. 2024 Jan;24(1):100-103. doi: 10.1080/15265161.2023.2278554. Epub 2024 Jan 18.PMID: 38236869

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Ethical issues of nosology in disorders of consciousness.Robbins NM, Bernat JLNeuroRehabilitation. 2024;54(1):3-9. doi: 10.3233/NRE-230120.PMID: 38277312

Selected Publications   Adam Omelianchuk, Alexander Morgan Capron, Lainie Friedman Ross, Arthur R. Derse, James L. Bernat, and David Magnus reply.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Sep;54(5):37-38. doi: 10.1002/hast.4920.PMID: 39487773The Unified Brain-Based Determination of Death Conceptually Justifies Death Determination in DCDD and NRP Protocols.Bernat JLAm J Bioeth. 2024 Jun;24(6):4-15. doi: 10.1080/15265161.2024.2337392. Epub 2024 Jun 3.PMID: 38829591Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Jul;54(4):14-23. doi: 10.1002/hast.1584. Epub 2024 May 20.PMID: 38768312Advancing the Scientific Basis for Determining Death in Controlled Organ Donation After Circulatory Determination of Death.Murphy NB, Shemie SD, Capron A, Truog RD, Nakagawa T, Healey A, Gofton T, Bernat JL, Fenton K, Khush KK, Schwartz B, Wall SPTransplantation. 2024 Nov 1;108(11):2197-2208. doi: 10.1097/TP.0000000000005002. Epub 2024 Apr 19.PMID: 38637919Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop.Khush KK, Bernat JL, Pierson RN 3rd, Silverman HJ, Parent B, Glazier AK, Adams AB, Fishman JA, Gusmano M, Hawthorne WJ, Homan ME, Hurst DJ, Latham S, Park CG, Maschke KJ, Mohiuddin MM, Montgomery RA, Odim J, Pentz RD, Reichart B, Savulescu J, Wolpe PR, Wong RP, Fenton KNAm J Transplant. 2024 Jun;24(6):918-927. doi: 10.1016/j.ajt.2024.03.015. Epub 2024 Mar 19.PMID: 38514013Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.Bernat JL, Khush KK, Shemie SD, Hartwig MG, Reese PP, Dalle Ave A, Parent B, Glazier AK, Capron AM, Craig M, Gofton T, Gordon EJ, Healey A, Homan ME, Ladin K, Messer S, Murphy N, Nakagawa TA, Parker WF, Pentz RD, Rodriguez-Arias D, Schwartz B, Sulmasy DP, Truog RD, Wall AE, Wall SP, Wolpe PR, Fenton KNJ Heart Lung Transplant. 2024 Jun;43(6):1021-1029. doi: 10.1016/j.healun.2024.02.1455. Epub 2024 Mar 2.PMID: 38432523The Uniform Law Commission and the Conceptual Basis for Brain Death: The UDDA Revision Series.Bernat JLNeurology. 2024 Mar 26;102(6):e209157. doi: 10.1212/WNL.0000000000209157. Epub 2024 Feb 26.PMID: 38408292Taking the pulse of brain death: A meta-analysis of the natural history of brain death with somatic support.Gambardella I, Nappi F, Worku B, Tranbaugh RF, Ibrahim AM, Balaram SK, Bernat JLEur J Neurol. 2024 May;31(5):e16243. doi: 10.1111/ene.16243. Epub 2024 Feb 20.PMID: 38375732Ethical issues of nosology in disorders of consciousness.Robbins NM, Bernat JLNeuroRehabilitation. 2024;54(1):3-9. doi: 10.3233/NRE-230120.PMID: 38277312The Brainstem Criterion of Death and Accurate Syndromic Diagnosis.Bernat JLAm J Bioeth. 2024 Jan;24(1):100-103. doi: 10.1080/15265161.2023.2278554. Epub 2024 Jan 18.PMID: 38236869View more publications on PubMed

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Taking the pulse of brain death: A meta-analysis of the natural history of brain death with somatic support.Gambardella I, Nappi F, Worku B, Tranbaugh RF, Ibrahim AM, Balaram SK, Bernat JLEur J Neurol. 2024 May;31(5):e16243. doi: 10.1111/ene.16243. Epub 2024 Feb 20.PMID: 38375732

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Professional Interests Brain death and the definition of death. Coma, vegetative states, and other disorder of consciousness. Ethical and philosophical issues in neurology. Grant Information SYNERGY: Dartmouth Center for Clinical and Translational Science. Director: Research Ethics Biography James L. Bernat, M.D., formerly the Louis and Ruth Frank Professor of Neuroscience at Dartmouth Medical School, earned a B.A. from the University of Massachusetts (1965-69) and an M.D. from Cornell University Medical College (1969-73). He trained in internal medicine and neurology at the Dartmouth-Hitchcock Medical Center (1973-77). Dr. Bernat has been a Dartmouth Medical School faculty member since 1976 and has held the rank of Professor of Medicine and Neurology since 1989. Dr. Bernat was the Director of the Program in Clinical Ethics at the Dartmouth-Hitchcock Medical Center. Previously he served as Assistant Dean of Clinical Education at Dartmouth Medical School. He served for 28 years on the American Academy of Neurology Ethics, Law & and Humanities Committee, with 10 years as chairman. Dr. Bernat has been elected to Phi Beta Kappa, Alpha Omega Alpha, and fellowships in the American College of Physicians, the American Academy of Neurology, the American Neurological Association, and The Hastings Center. In 2011, he received the Presidential Award from the American Academy of Neurology for lifetime service to American neurology. In 2022, he received the Steven E. Hyman Award for Distinguished Service to the Field of Neuroethics from the International Neuroethics Society. Dr. Bernat's scholarly interests are in ethical and philosophical issues in neurology. He has authored over 300 articles and chapters on topics in neurology and clinical ethics. He is the author of Ethical Issues in Neurology, 3rd ed. (Lippincott Williams & Wilkins, 2008), coeditor of Palliative Care in Neurology (Oxford University Press, 2004), coeditor of Ethical and Legal Issues in Neurology (Elsevier, 2013), and coeditor of Death Determination by Neurologic Criteria: Areas of Controversy and Consensus (Springer, 2022). He testified on the vegetative state before the United States Senate Health Committee and was a consultant on brain death to the Institute of Medicine, the Vatican Pontifical Academy of Sciences, and the Pontifical Academy for Life. He chaired the US DHHS HRSA Division of Transplantation panel on determining death in organ donors, served on the World Health Organization international committee on standards for death determination, and cochaired the 2023 NIH Conference on Circulatory Death Determination. Selected Publications   Adam Omelianchuk, Alexander Morgan Capron, Lainie Friedman Ross, Arthur R. Derse, James L. Bernat, and David Magnus reply.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Sep;54(5):37-38. doi: 10.1002/hast.4920.PMID: 39487773The Unified Brain-Based Determination of Death Conceptually Justifies Death Determination in DCDD and NRP Protocols.Bernat JLAm J Bioeth. 2024 Jun;24(6):4-15. doi: 10.1080/15265161.2024.2337392. Epub 2024 Jun 3.PMID: 38829591Neither Ethical nor Prudent: Why Not to Choose Normothermic Regional Perfusion.Omelianchuk A, Capron AM, Ross LF, Derse AR, Bernat JL, Magnus DHastings Cent Rep. 2024 Jul;54(4):14-23. doi: 10.1002/hast.1584. Epub 2024 May 20.PMID: 38768312Advancing the Scientific Basis for Determining Death in Controlled Organ Donation After Circulatory Determination of Death.Murphy NB, Shemie SD, Capron A, Truog RD, Nakagawa T, Healey A, Gofton T, Bernat JL, Fenton K, Khush KK, Schwartz B, Wall SPTransplantation. 2024 Nov 1;108(11):2197-2208. doi: 10.1097/TP.0000000000005002. Epub 2024 Apr 19.PMID: 38637919Research opportunities and ethical considerations for heart and lung xenotransplantation research: A report from the National Heart, Lung, and Blood Institute workshop.Khush KK, Bernat JL, Pierson RN 3rd, Silverman HJ, Parent B, Glazier AK, Adams AB, Fishman JA, Gusmano M, Hawthorne WJ, Homan ME, Hurst DJ, Latham S, Park CG, Maschke KJ, Mohiuddin MM, Montgomery RA, Odim J, Pentz RD, Reichart B, Savulescu J, Wolpe PR, Wong RP, Fenton KNAm J Transplant. 2024 Jun;24(6):918-927. doi: 10.1016/j.ajt.2024.03.015. Epub 2024 Mar 19.PMID: 38514013Knowledge gaps in heart and lung donation after the circulatory determination of death: Report of a workshop of the National Heart, Lung, and Blood Institute.Bernat JL, Khush KK, Shemie SD, Hartwig MG, Reese PP, Dalle Ave A, Parent B, Glazier AK, Capron AM, Craig M, Gofton T, Gordon EJ, Healey A, Homan ME, Ladin K, Messer S, Murphy N, Nakagawa TA, Parker WF, Pentz RD, Rodriguez-Arias D, Schwartz B, Sulmasy DP, Truog RD, Wall AE, Wall SP, Wolpe PR, Fenton KNJ Heart Lung Transplant. 2024 Jun;43(6):1021-1029. doi: 10.1016/j.healun.2024.02.1455. Epub 2024 Mar 2.PMID: 38432523The Uniform Law Commission and the Conceptual Basis for Brain Death: The UDDA Revision Series.Bernat JLNeurology. 2024 Mar 26;102(6):e209157. doi: 10.1212/WNL.0000000000209157. Epub 2024 Feb 26.PMID: 38408292Taking the pulse of brain death: A meta-analysis of the natural history of brain death with somatic support.Gambardella I, Nappi F, Worku B, Tranbaugh RF, Ibrahim AM, Balaram SK, Bernat JLEur J Neurol. 2024 May;31(5):e16243. doi: 10.1111/ene.16243. Epub 2024 Feb 20.PMID: 38375732Ethical issues of nosology in disorders of consciousness.Robbins NM, Bernat JLNeuroRehabilitation. 2024;54(1):3-9. doi: 10.3233/NRE-230120.PMID: 38277312The Brainstem Criterion of Death and Accurate Syndromic Diagnosis.Bernat JLAm J Bioeth. 2024 Jan;24(1):100-103. doi: 10.1080/15265161.2023.2278554. Epub 2024 Jan 18.PMID: 38236869View more publications on PubMed

The Unified Brain-Based Determination of Death Conceptually Justifies Death Determination in DCDD and NRP Protocols.Bernat JLAm J Bioeth. 2024 Jun;24(6):4-15. doi: 10.1080/15265161.2024.2337392. Epub 2024 Jun 3.PMID: 38829591

Brain death and the definition of death. Coma, vegetative states, and other disorder of consciousness. Ethical and philosophical issues in neurology.