Feeler Gauges | Specialty Tools & Shop Equipment - feeler guage

2024-10-11 23:53:48

1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

If the seal that is part of the bearing fails, moisture and dirt can enter the bearing’s grease, compromising the grease’s ability to keep the load bearing elements (balls and races) lubricated. But there are times when a bearing destroys itself even though the grease is not compromised. Tiny particles of metal can begin to flake off of the races, and when this happens, those particles mix with the grease so that it becomes a grinding compound of sorts, creating a “snowball” effect whereby more metal flakes off and enters the grease charge and the bearing gets noisier with time.

A faulty wheel bearing can cause your vehicle to pull to one side during braking. This symptom can also be related to faulty brake components.

3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

A bad wheel bearing can cause the brake rotor to wobble, which shoves the caliper piston back into its bore so that when you apply the brakes, you have unexpected pedal travel as a result – making it harder to stop or causing the vehicle to pull unexpectedly to one side – never a good thing in traffic.

3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Subjects with known or suspected SpA will provide informed consent and then be evaluated either in the outpatient or inpatient unit of the NIH Clinical Center. To be eligible for follow-up visits patients must meet the Inclusion Criteria, but not the Exclusion criteria. Subjects determined to not have SpA will not be followed. Patients with signs and symptoms of SpA will be classified as outlined in #1 and #2 below: 1. Patients less than 16 years of age will be considered to have SpA if they meet the ILAR criteria for ERA (without or with psoriasis or a positive family history of psoriasis), or modified NY criteria for AS. 2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Wheel bearings support the weight of the vehicle and allow the wheel/tire assembly to rotate when you’re traveling down the road. All four of your car’s wheels have wheel bearings and they are designed to last the life of the vehicle. In fact, many vehicles will travel hundreds of thousands of miles/kilometers and never need a wheel bearing replacement, but others may need one or more wheel bearings replaced over their lifetime.

Richard McCuistian has worked for nearly 50 years in the automotive field as a professional technician, an instructor, and a freelance automotive writer for Motor Age, ACtion magazine, Power Stroke Registry, and others. Richard is ASE certified for more than 30 years in 10 categories, including L1 Advanced Engine Performance and Light Vehicle Diesel.

The older style cone shaped bearings have a series of tapered rollers in a cage with a window for each roller to keep them evenly spaced while they ride between inner and outer races. But most modern sealed bearings have steel balls with inside and outside races.

EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Patients with signs and symptoms of SpA will be classified as outlined in #1 and #2 below: 1. Patients less than 16 years of age will be considered to have SpA if they meet the ILAR criteria for ERA (without or with psoriasis or a positive family history of psoriasis), or modified NY criteria for AS. 2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

One tricky thing about wheel bearing noise is that a bad tire can make almost exactly the same noise as a bad bearing; you don’t want to replace a wheel bearing for a noise concern when all you need is a new tire.

EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Also, by replacing a bad bearing early on, you can also save yourself a lot of money by avoiding possible major repairs.

Proco PEN-SEAL links may be sized by using the chart below. The following pipe materials penetration seal measurements are listed for sizing and selection.

Since the wheel bearings keep the wheel and hub assembly spinning on an axis, if the wheel bearing is compromised to the point that it can no longer maintain that axis, driving with a faulty bearing can be extremely dangerous—especially at high speeds. Think about a wheel that starts wobbling because the bearing decided to completely come apart while you’re in freeway traffic. This can happen without warning if you’ve become accustomed to the bearing’s noise as it continues to warn you by getting louder.

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Can your car still run with a faulty bearing? The technical answer might be yes; some wheel bearings might continue to operate normally despite the vehicle being driven with one or more noisy bearings for a very long time. The problem is that since the noise begins gradually and slowly gets worse, you might not even notice the noise if your vehicle is noisy in other ways.

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Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

You might have seen a vehicle pulling trailer that has had the bearings neglected to the point that the wheel gets hot enough to set the tire on fire – it can happen on your vehicle in extreme cases, but it’s rare.

- To identify symptoms and medical tests that can help determine whether a person with SpA is at risk for developing more severe forms of the disease.

Once again, there are other issues besides a bad wheel bearing that can cause steering wheel vibrations. A thorough diagnosis is needed to verify the cause of the concern.

Wheel bearing failure is a potentially dangerous situation at any time, so have your vehicle towed to the nearest mechanic and have your faulty wheel bearings replaced right away. Vehicle safety should always come first.

INCLUSION CRITERIA: Subjects with known or suspected SpA will provide informed consent and then be evaluated either in the outpatient or inpatient unit of the NIH Clinical Center. To be eligible for follow-up visits patients must meet the Inclusion Criteria, but not the Exclusion criteria. Subjects determined to not have SpA will not be followed. Patients with signs and symptoms of SpA will be classified as outlined in #1 and #2 below: 1. Patients less than 16 years of age will be considered to have SpA if they meet the ILAR criteria for ERA (without or with psoriasis or a positive family history of psoriasis), or modified NY criteria for AS. 2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group. --Back to Top-- Citations: Not Provided --Back to Top-- Contacts: Principal Investigator Referral Contact For more information: Robert A. Colbert, M.D. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) NIHBC 10 - CLINICAL CENTER BG RM 12N240E 10 CENTER DR BETHESDA MD 20892 (301) 443-8935 colbertr@mail.nih.gov

Is your ABS light on, and you do not know what is causing it? A faulty wheel bearing can be a possibility. On some vehicles, the ABS sensor or encoder ring is integrated into the wheel hub and bearing assembly. As such, a failure of the wheel bearing can trigger the ABS light.

1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Another tricky element of wheel bearing noise is the need to pinpoint which wheel bearing is making the noise. Sometimes even professional mechanics will struggle with this, and there are special listening devices shops use to pinpoint which bearing is making the noise. Some tire shops will replace both front bearings if there is a bearing noise coming from the front of the vehicle; not a bad practice, actually.

Pro Tip: If a noise happens after the tires are rotated on a front wheel drive vehicle, it may be due to the wear pattern on the tires, so be aware of that, too.

In cases like that, or when you just decide to keep driving until the failure is complete, the bearing itself will decide for you when it must be changed, and it can do so in very unpleasant ways and never at a good time. In other words, there are instances, when left unattended to, a faulty wheel bearing can create hazardous conditions, such as the following:

4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

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- No treatment will be provided, although treatment options will be discussed. --Back to Top-- Eligibility INCLUSION CRITERIA: Subjects with known or suspected SpA will provide informed consent and then be evaluated either in the outpatient or inpatient unit of the NIH Clinical Center. To be eligible for follow-up visits patients must meet the Inclusion Criteria, but not the Exclusion criteria. Subjects determined to not have SpA will not be followed. Patients with signs and symptoms of SpA will be classified as outlined in #1 and #2 below: 1. Patients less than 16 years of age will be considered to have SpA if they meet the ILAR criteria for ERA (without or with psoriasis or a positive family history of psoriasis), or modified NY criteria for AS. 2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group. --Back to Top-- Citations: Not Provided --Back to Top-- Contacts: Principal Investigator Referral Contact For more information: Robert A. Colbert, M.D. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) NIHBC 10 - CLINICAL CENTER BG RM 12N240E 10 CENTER DR BETHESDA MD 20892 (301) 443-8935 colbertr@mail.nih.gov April Brundidge, R.N. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) National Institutes of Health Building 10 Room 6N216 10 Center Drive Bethesda, Maryland 20892 (301) 443-5407 brundidgea@mail.nih.gov

1. Patients less than 16 years of age will be considered to have SpA if they meet the ILAR criteria for ERA (without or with psoriasis or a positive family history of psoriasis), or modified NY criteria for AS. 2. Patients 16 years of age or older will be considered to have SpA if they have previously met ILAR criteria for ERA, or currently meet ESSG or Amor criteria for USpA, ASAS criteria for Axial SpA, or modified NY criteria for AS. 3. Family members of individuals included under items 1 and 2. Family members will not be asked to submit to bone marrow aspiration or interruption of therapy. 4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

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1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

- Spondyloarthritis (SpA) is a group of bone and joint disorders that may cause back and joint pain and stiffness. In some cases, SpA can lead to abnormal bone growth affecting the joints and spine. Some patients have SpA without ever developing these growths, while others develop them after only a few years. Researchers are interested in studying people with SpA and their relatives to determine which people are more likely to develop more severe conditions.

Note by Richard McCuistian, ASE-certified mechanic: I have personally seen a Crown Victoria that was making a noise I would have sworn was coming from the left rear axle bearing, but after removing and inspecting that bearing (which is difficult on a rear wheel drive vehicle), I discovered that the noise was actually originating from the left front tire. And I had nearly 40 years of automotive experience at the time.

5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

In the event that this happens under weather conditions that make the road slippery, immediately maneuver your vehicle to the nearest safe spot off the road.

2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

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When you’re driving with the music cranked up, you may not notice the different sounds that your vehicle makes. But the moment you turn the radio off and notice a growling, humming, or rumbling noise coming from your wheel bearing, you’ll know there’s a problem.

Wheel bearing noise coincides with the rotation of the tires. The sound typically increases with vehicle speed as well. In some instances, the noise may also change when you turn the steering wheel in one direction or the other.

Remember, the wheel bearing not only allows the wheel/tire assembly to rotate along with the hub the wheel is bolted to, the bearing also carries the weight of the vehicle and maintains the spinning wheel’s axis by keeping it in a straight line. A failed wheel bearing won’t usually allow the wheel to come off completely unless the bearing has become so hot that the axle or spindle is glowing red. Not only can this cause a fire in the wheel well area, the wheel and hub can separate from the vehicle and… well, finish the thought. Granted, this is a very extreme case of a wheel bearing failure, but wheel bearings that have lost their grease can get extremely hot.

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2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Loose wheel bearings can throw your car’s alignment off, leading to abnormal tire wear. There are, of course, many other problems that can create the same, undesirable results. So, you’ll want to diagnose the issue thoroughly before condemning one or more of the wheel bearings

Wheel bearings are in a hostile environment and are working very hard, but wheel bearings are very tough – they’re designed for the work they do. But product variability is a real thing, and again, some bearings fail while others never do.

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Mechanics will find a safe, empty, smooth paved road, then listen carefully to the noise while swerving gently from side to side – typically when you swerve to the right, you’re increasing the load on the left side bearings, and vice versa. And again, while this is a good practice, it’s easy to be fooled into replacing the wrong bearing, even using this method – that’s why some tire shops replace bearings in pairs. If you use this method and believe the noise is tire related, you can move the front tires to the rear and see if the noise changes.

It’s this abnormal sound that’s the most obvious sign something is wrong with your wheel bearings. Of course, because other issues, such as cupped tires, can mimic a bad wheel bearing, you’ll want to diagnose the sound properly.

4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Some may say that you can drive for up to a thousand miles with a failed wheel bearing—but the thing is, this is an arbitrary claim. There’s really no telling how long you can safely drive your vehicle in this state. It would depend on the severity of the damage to your wheel bearing, present road conditions, and other factors. So, it’s best not to push your luck.

A faulty wheel hub and bearing assembly can also cause a vibration felt in the steering wheel. Often, the sensation will change with vehicle speed or while the vehicle is cornering.

2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

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It’s worth noting that tire noise will usually change depending on the road surface. Wheel bearing noise, on the other hand, is consistent regardless of road surface and acceleration.

4. Controls for clinical, cellular, molecular, and biochemical assays, and genetic evaluation will be enrolled. Individuals who undergo phlebotomy specifically to provide a control specimen will be 6 years of age or older, and not pregnant. 5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

The wheel bearing on a wheel usually consists of a pair bearing assemblies running side by side on the shaft or spindle – this keeps the spindle running straight, while a single row of balls or rollers might allow the wheel to wobble. Exceptions would be the non-tapered roller bearings on rear wheel drive vehicles, which will have only one bearing assembly at the wheel end of the axle, but the inboard end of the axle on those units is splined to the differential assembly, which is spinning in its own set of tapered roller bearings.

Thank for pointing out that typo. The paragraph was supposed to read: Some front-wheel drive vehicles have wheel bearings of this type on the rear. We have updated the article.

5. Minor healthy volunteers undergoing imaging (SI and/or WB MRI) must be old enough to complete the procedure without sedation. Generally this requires that they be at least 6 years of age, so no healthy volunteers under age 6 will be enrolled. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, confuse the interpretation of the study. 3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

By now, you may have an idea of how important wheel bearings are. Thankfully, there are signs that can indicate that your wheel bearings are going bad.

There are different kinds of wheel bearings depending on the year model and the design of the vehicle. Older rear wheel drive vehicles had cone type wheel bearings on the front wheels that could be removed, inspected, and packed with grease, and reinstalled with new seals. Some front-wheel drive vehicles have wheel bearings of this type on the rear. In other words, if a vehicle has cone-type bearings that can be removed, inspected, and repacked, it will always be on the NON-driving wheels – the ones that don’t propel the vehicle. Trailer wheels often have bearings of this type.

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This paragraph doesn’t make sense: Older rear wheel drive vehicles had cone type wheel bearings on the front wheels that could be removed, inspected, and packed with grease, and reinstalled with new seals. Some rear wheel drive vehicles have wheel bearings of this type on the rear. In other words, if a vehicle has cone-type bearings that can be removed, inspected, and repacked, it will always be on the NON-driving wheels – the ones that don’t propel the vehicle.

A worn-out wheel bearing may also make a high-pitched squealing sound while you’re driving. If you are able to observe these symptoms, have your vehicle checked right away. Even if your wheel bearings are not the culprit—there’s definitely something wrong with your vehicle.

If your wheel bearing goes out while you’re on the road, it’s not advisable to keep driving. However, if there’s absolutely no alternative, make sure to maintain a slow and steady pace—do not accelerate or turn suddenly.

- Participants with SpA will have imaging studies, including magnetic resonance imaging (MRI). Other samples such as skin tissue and bone marrow may also be collected for study.

3. Unavailability, or inability to comply with the schedule for follow-up visits. 4. Pregnant women will be excluded from enrolling. 5. Children under the age of 2 years old. Fecal Microbiota Study Inclusion/Exclusion Criteria: INCLUSION CRITERIA: 1. Subjects must be enrolled on another NIH natural history protocol, including either 14-AR-0200 (Studies on the Natural History, Pathogenesis and Outcome of Idiopathic Systemic Vasculitis, P. Grayson PI); 18-AR-0081 (Investigation of the Natural History, Genetics, and Pathophysiology of Systemic Juvenile Idiopathic Arthritis, Adult-Onset Still s Disease and Related Inflammatory Conditions, M. Ombrello PI), or 94-E-0165 (Studies in the Natural History and Pathogenesis of Childhood-Onset and Adult-Onset Idiopathic Inflammatory Myopathies, Lisa Rider PI), and meet the respective protocol s criteria for a diagnosis of systemic vasculitis, systemic juvenile idiopathic arthritis, or dermatomyositis. 2. Subjects with definite SpA enrolled on 11-AR-0223 are eligible for the Fecal Microbiota sub-study. 3. Healthy volunteers enrolled on the above protocols are also eligible. EXCLUSION CRITERIA: 1. Inability to provide informed consent or, in the case of minors, unavailability of a parent or guardian. 2. Presence of any medical condition that would, in the opinion of the investigators, expose subjects to more than minimal risk, or confuse the interpretation of the study. 3. Pregnant women are excluded from enrolling. 4. Subjects (including healthy volunteers) less than 4 years of age are excluded due to the challenging practical considerations of collecting stool samples, and because spondyloarthritis is much less common in this age group.

Pro Tips are nuggets of information direct from ASE-certified automobile technicians working with CarParts.com, which may include unique, personal insights based on their years of experience working in the automotive industry. These can help you make more informed decisions about your car.

I have personally seen a Crown Victoria that was making a noise I would have sworn was coming from the left rear axle bearing, but after removing and inspecting that bearing (which is difficult on a rear wheel drive vehicle), I discovered that the noise was actually originating from the left front tire. And I had nearly 40 years of automotive experience at the time.

- Participants with SpA will have a physical exam and medical history, including a study of joint movement, blood and urine tests, and questionnaires about pain and quality of life.

Modern vehicles have sealed wheel bearings that cannot be disassembled without destroying the wheel bearing assembly in the process, and on vehicles with bearings like those, you only know a bearing is bad when it begins to make noise. That’s the earliest indication of a bad wheel bearing, and front wheel bearings (both on front wheel drive as well as rear wheel drive vehicles) are the most prone to fail on modern vehicles.

- Participants will be screened with medical records and family medical histories, and will be invited to the clinical center for the study.

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