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b) Patient Interviews (10-15 patients per centre) at different stages of breast cancer treatment from 14 centres comprising 12 countries including North, Central and Southern Europe and Asia.

a) Pre-testing the new module for understanding, comprehensiveness and applicability (according to the EORTC Module Development Guidelines)

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The aim of this study is to create a QoL questionnaire with more relevant questions related to new treatment options. This process will cover:

One of the first questionnaires developed was the EORTC QLQ-BR23 published in 1996 and used by numerous researchers and doctors since then. However, standard treatments for breast cancer have changed in the past 15 years (e.g. types of surgery to the breast and axilla, radiotherapy and drugs used). New treatments have brought new side-effects and changes to QoL that are presently not well covered by the EORTC QLQ-BR23. An update of the questionnaire will be important, both from a clinical and scientific point of view.

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a) Operationalization of the issues into patient-reported questions or items (as the questionnaire is developed)b) Interviews with 1-2 Health Care Professionals per country

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a) Systematic Review of the literatureb) Interviews with at least 60 breast cancer patients (5-10 from each centre) and Health Care Professionals (5 per country)Phase II:

Breast cancer is a chronic disease resulting in a long lifetime for patients with side-effects of disease and treatments. However, it is still the most frequent type of cancer in Europe (55,000 women annually). Therefore there is growing interest in women's quality of life (QoL) and effects of treatment for breast cancer survivors. Health related QoL (HRQL) is recognised to play an important role in breast cancer care.