Highest antigen sequence indentity to the following orthologs: Mouse (96%), Rat (96%).This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-66521. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

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ELF5 is a member of an epithelium-specific subclass of the Ets transcritpion factor family. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus.

蛋白别名: E74-like factor 5; E74-like factor 5 (ets domain transcription factor); elf-5; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2; ESE-2; ETS-related transcription factor Elf-5