It’s a sound every motorist dreads hearing—an unexpected scraping or grinding noise when you’re driving your vehicle. There are a few possible reasons why you might hear this, but none of them are good. In almost every case, it means that parts are touching that shouldn’t be touching (at least, not so hard).

Previous studies were mostly based on single-institution experience and focused on one specific primary cancer site; therefore, the survival time of secondary liver cancer patients was rarely described systematically with respect to the primary sites. For example, in secondary liver patients deriving from colorectum who undergo primary tumor resection, the mean survival is approximately 6-9 months (19,20). Another study reported that for secondary liver cancer patients deriving from breast cancer, the median OS was 7 months (21). One epidemiological study on secondary liver cancer patients deriving from adenocarcinoma and small cell lung cancer showed the mean OS was 3 months and 4 months, respectively (22). Owing to the bias caused by the inclusion criteria, number of participants, data sources, and the survival time reported in different studies varies greatly, highlighting the need for the current study to help fill in the gaps. In contrast, this bias was reduced in our study, hence providing more objective and accurate findings. Overall, we performed a horizontal comparison among secondary liver cancer patients from the six most common primary sites, and found that patients whose primary sites were the colorectum, breast, and cecum had longer CSS than those whose primary sites were the stomach, lung, and pancreas.

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But how can you tell where the grinding noise in your vehicle is coming from—and what can you do to prevent or stop it? That’s what we’ve explained below. Keep reading to find out about the most common causes of grinding noises in cars and trucks so you can identify the source of these noises when your vehicle starts making them and replace the appropriate parts.

The lifespan of a wheel bearing and hub assembly varies based on several factors, of which the vehicle's overall condition and typical operating environment are major factors. However, all things being equal, variance is surprisingly minimal.

We found that advanced age, male gender, black race, poor differentiation or lack of differentiation, and regional lymph node metastases were associated with worse prognosis; however, the impact of race and tumor size were not obvious. Tumor size is closely correlated with the cancer stage at diagnosis (17). Generally, patients with small tumor size are asymptomatic, and computed tomography, magnetic resonance imaging, or positron emission tomography are not performed unless metastatic disease is suspected (5,18). Therefore, we speculate that patients with small tumors included in our study were diagnosed at an early stage due to their more severe clinical manifestations, which weakened the association between tumor size and prognosis. Nevertheless, liver function and other clinical indexes were not available during our study; hence, this speculation must be verified through further research.

Despite these limitations, our study is the most comprehensive population-based analysis for secondary liver cancer. These findings can help oncologists and hepatologists design personalized treatment and appropriate follow-up strategy, and provide a better understanding of secondary liver cancer for the general population.

Results of the multivariate analysis indicated that advanced age, male gender, black race, poor differentiation or lack of differentiation, and regional lymph node metastases were associated with poor prognosis (Table 4). Patients with the pancreas, lung or stomach as the primary site had a higher risk of poor outcomes. (Table 4).

Keywords: Secondary liver cancer; epidemiology; prognosis; primary site; Surveillance, Epidemiology, and End Results (SEER)

Brakesgrinding while driving

Population-based incidence and survival studies can provide valuable information for clinicians, researchers, and public health officials; these can also guide the direction of future research. In this study, we described the incidence, survival outcomes and prognostic factors of secondary liver cancer. Our findings indicate that the most common primary site was the lung, followed by the colorectum and pancreas, consistent with the findings of previous studies (6,13). However, Bosch et al. (14) established the breast as the most common primary site. This difference can be mainly attributed to the inclusion criteria set for study participants. Lung and pancreatic metastases are commonly synchronous, but breast metastasis tends to be metachronous (15,16). Moreover, the median disease-free interval before clinical liver metastasis for breast cancer patients is 20.2 months (16).

Although the global incidence and mortality rates of liver cancer are increasing, imposing a huge burden on the health care system (3), information regarding the epidemiology and clinical prognosis of secondary liver cancer is still limited. Using data from the Surveillance, Epidemiology, and End Results (SEER) database, we conducted a population-based analysis to comprehensively identify the epidemiological characters and prognostic factors of secondary liver cancer, to potentially help clinicians make better clinical decisions during pretreatment evaluation. We present the following article in accordance with the STORBE reporting checklist (available at http://dx.doi.org/10.21037/tcr-20-3319).

Grinding while drivingbut not brakes

1Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 2Department of Information Management, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; 3Department of Management and Consultation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Grindingnoise whendrivingat low speeds

Contributions: (I) Conception and design: ZG Wang, XL Du; (II) Administrative support: YY Chen, XL Du; (III) Provision of study materials or patients: ZY He, H Gao; (IV) Collection and assembly of data: YY Chen, H Gao; (V) Data analysis and interpretation: ZG Wang, YY Chen; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.

And no, before you ask—you can’t just keep braking on your rotors and then replacing them. Those longer stopping distances put you and everyone else on the road at risk—and it will wear down other parts of your braking system more quickly, too.

However, issues with brake pads and rotors can also come with a few other signs, which can help you distinguish between them and bearing or hub problems. Here are a few of the most common:

The authors acknowledge Xudong Yao for assistance in using the SEER*Stat 8.3.5 software, and the efforts of the National Cancer Institute.

Liver cancer is the fifth and ninth most common cancer in male and female, respectively (1). It is the second leading cause of cancer-related death worldwide (1,2). In 2012, 782,500 newly diagnosed liver cancer cases and 745,500 deaths due to the same were estimated globally (2,3). Moreover, secondary liver cancer is more common than primary liver cancer (4-6).

Covariates included demographic variables (age at diagnosis, gender, race) and diagnostic information (primary site, tumor size, grade, lymph nodes stage, and synchronous additional distant metastasis to specific organs). The outcome measures were overall survival (OS, time from the diagnosis of secondary liver cancer to by any cause) and cancer-specific survival (CSS, time from the diagnosis of secondary liver cancer to death by cancer). We used the term “unknown” to represent missing data and treated it as an independent variable during analysis.

Results: A total of 85,738 secondary liver cancer patients were identified; in this population, the first primary site was the lung (25.9%), followed by the colorectum, pancreas, stomach, breast, and cecum. Patients with primary tumors of the colorectum, cecum and breast had longer median survival time. Advanced age, male gender, black race, poor differentiation or lack of differentiation, regional lymph node metastases, and presence of distant metastasis were associated with poor prognosis.

Grindingnoise when accelerating at low speed

Reporting Checklist: The authors have completed the STORBE reporting checklist. Available at http://dx.doi.org/10.21037/tcr-20-3319

The present study has some potential limitations. First, the SEER database did not include information on synchronous distant metastasis to specific organs until 2010; therefore, the follow-up period was not long enough. Second, we were limited to the information that the SEER database provided; hence, systemic therapy, other metastatic sites, and physical condition of patients that may relate to prognosis were not considered.

Grindingnoise when accelerating

A current study reported that circulation patterns, extravasation barriers, and survival on arrival are three key determinants of the capacity of particular tumors to seed specific organs (32). Furthermore, the microenvironment, chemokines, and microRNAs are being widely investigated to reveal the molecular mechanisms of metastatic organ tropism (32-35). Based on our findings, we conclude that there may be interactions between synchronous distant metastases and the primary sites in secondary liver cancer, which influence its incidence and prognosis, and this conclusion provides clinical evidence for basic research.

The number of patients who had synchronous distant metastasis to specific organs was limited; hence, we analyzed this variable in specific cohorts. In the cohort of patients under the first six primary sites, the site specific HR for metastasis were: brain, CSS: 1.189, P<0.001; lung, CSS: 1.154, P<0.001; and bone, CSS: 1.096, P<0.001 (Table 4). In the cohort of patients with colorectum as the primary site, combined with bone metastasis had the worst CSS (HR: 1.402, P<0.001). In the cohort of patients with pancreas as the primary site, combined with brain metastasis had the worst CSS (HR: 1.61, P=0.007). In the cohort of patients with the lung as the primary site, HR for metastasis showed no significant difference (Table 5).

Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/tcr-20-3319). The authors have no conflicts of interest to declare.

It’s the same when it comes to brakes—replacing your rotors usually costs hundreds of dollars more than simply replacing your pads. You can normally replace your pads for less than $200, but you’ll pay at least that much again for new rotors as well.

Driving with worn out bearings can eventually lead to problems with your drive shaft—and by proxy, your transmission. Buying replacement bearings for most vehicles is fairly inexpensive, but transmission replacement often costs around $5000. You do the math, and tell us what option is actually better for your bank account!

A total of 85,738 patients with secondary liver cancer were included in our study. As shown in Table 1, majority of the secondary liver cancers originated from the digestive system (56.9%), and the six most common primary sites were the lung (25.9%), colorectum (21.4%), pancreas (19.6%), stomach (4.6%), breast (4.4%) and cecum (4.1%). When stratified by race, the first primary site was the lung for White and the colorectum for Black or Others patients. Interestingly, there was a significant number of male cases whose primary site was esophagus or stomach (male: female=10.5:3.7).

Considering that unspecific or unknown primary sites, as well as the shortage of cases could contribute as potential confounding factors, we only showed patient characteristics for those who had secondary liver cancer from the top six primary sites described above (Table 2). For patients with breast as the primary site, the proportion below the age of 40 was high. We also observed that patients, whose primary sites were the lung or breast, were more likely to have synchronous distant metastasis, especially bone metastasis.

The liver is one of the most common sites for organ-specific metastasis (7), which is mainly attributable to the organ-specific circulation pattern and distinct anatomy of microvessels (8). The liver has a unique dual blood supply system from both the portal vein and the hepatic artery, which increases the possibility of metastatic deposition. In addition, the sinusoidal hepatic endothelial layer is characterized by an incomplete covering of the microvessel structures (9); consequently, the extracellular matrix components are directly accessible to the circulating cells (9,10).

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Once you’ve determined the cause of the grinding sound your vehicle is making, you’ll want to replace the worn out components as soon as you can. While it might be tempting to drive around in a car with worn out bearings or a truck with thin brake pads until your next paycheck, we don’t recommend trying it. That’s because doing so can cause wear and tear to the parts of your vehicle those components are meant to protect.

Some newer cars also have an indicator light that only goes on when your brake pads are significantly worn down. If your vehicle has one of these and you notice it turn on, take your car or truck in for a brake inspection as soon as possible.

As the SEER database is publicly available, and the data used in this study did not include specific patient identifiers, the study did not require a review by the ethics committee. The SEER program is a premier source of cancer statistics in the United States and collects data from 18 population-based central cancer registries while covering 27–30% of the US population (11). SEER*Stat 8.3.5 (National Cancer Institute, MD, USA) software was used to extract the data. We identified 85,738 patients, whose liver metastases were synchronous to the primary tumor as secondary liver cancer patients diagnosed between 2010 and 2014. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).

Grindingnoise from front wheel whendriving

Aims and ScopeTranslational Cancer Research (Transl Cancer Res TCR; Print ISSN: 2218-676X; Online ISSN 2219-6803; https://tcr.amegroups.com/) is an Open Access, peer-reviewed journal, indexed in PubMe...

Your braking system consists of brake pads, which are applied to the rotors on your vehicle’s wheels by callipers. When the pads wear down, the callipers can press directly on the rotors themselves, causing a squealing or grinding sound similar to the one worn out bearings cause.

Methods: Patients diagnosed with secondary liver cancer between 2010 and 2014 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively included. Kaplan-Meier analysis and Multivariate Cox regression analysis were performed to screen for significant factors associated with secondary liver cancer.

Conclusions: In this study, novel findings on the role of the primary site and synchronous distant metastasis to specific organs in patients with secondary liver cancer were described. These findings have significant implications in clinical diagnosis and treatment, and provide a better understanding of secondary liver cancer in the general population.

Interestingly, we found that for secondary liver cancer patients deriving from colorectum, bone metastasis was a poor prognostic factor, as compared to metastases in other organs. Bone metastasis is very rare and the prognosis for colorectal cancer is poor (23-25). Moreover, numerous skeletal-related clinical events may occur in patients with bone metastasis, which decreases the patients’ functionality and quality of life (26,27). Early secondary liver cancer is asymptomatic, whereas bone metastasis is often symptomatic; therefore, bone metastasis could act as a warning signal during disease screening. We also found that for patients deriving from pancreas, brain metastasis was a poor prognostic factor. It is extremely rare in pancreatic cancer and only a few case reports exist for reference (28). In most of the reported cases, the disease had rapidly progressed, and the patients soon died after palliative treatment (28-30). Moreover, patients benefit poorly from surgical resection of brain metastases (30,31).

Ethical Statement: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013).

Intermittentgrindingnoise whendriving

While a grinding noise is likely the first sign of a bad wheel bearing that you’ll notice, it’s not the only one. Worn out wheel bearings can also result in the following issues:

Among the total study population, the median and average OS were 3 months and 7.680±10.467 months, respectively, and that for CSS were 2 months and 5.820±8.015 months, respectively (Table 3). The OS and CSS Kaplan–Meier curves showed significant differences in survival outcomes according to primary sites (Figure 1). The median CSS of patients with the colorectum as the primary site was 6 months, which was greater than that of patients with other primary sites. Patients whose primary sites were the lung and pancreas had the worst median CSS of 2 months (Table 3).

The moral of the story? Learn to properly identify and diagnose the grinding sounds your vehicle makes so you can order the right replacement parts and take care of the problem before it gets worse!

Wheel bearings sit inside the hub assembly on each wheel of your vehicle. Their job is to help each wheel of the vehicle turn smoothly while you’re driving.

The ABS light turning on: since many hubs in modern vehicles are connected to the ABS systems, a damaged hub may cause the ABS light in your vehicle’s dashboard to activate. In these cases, the entire hub assembly (including bearings) will normally need replacement.

Grindingnoise whendrivingat high speeds

Sometimes, elements can get inside the hub assembly and cause extra resistance as the wheel bearings are moving, preventing them from effectively reducing friction as your wheels are spinning. Wheel bearings can also fail due to a lack of proper lubrication, as well as simple wear-and-tear over time.

Kaplan-Meier analysis and log-rank test were used to estimate and compare the outcomes between different primary sites. Multivariate Cox regression models were conducted after adjusting for various covariates to assess the prognostic factors associated with OS and CSS. Hazard ratio (HR) with corresponding 95% confidence interval (95% CI) was used to show the effect of different variables on OS and CSS (12). All tests were two-sided, and P<0.05 was considered statistically significant. Statistical analyses were performed using SPSS version 21.0 (IBM Corp, Armonk, NY, USA).

Background: The global incidence and mortality rates of liver cancer, which is the second leading cause of cancer-related deaths worldwide, are increasing. However, information on its epidemiology and clinical prognosis is limited. This study aimed to characterize the epidemiology and prognostic factors of secondary liver cancer to aid in the pretreatment evaluation of the disease.

The noises these issues make can sound the same if you don’t know what to pay attention to, so let’s take a closer look at each—including when it’s most likely to happen. That way, you should be able to get a better idea of which issue you’re dealing with when you hear grinding in your own vehicle.

Funding: This study was supported by a Fundamental Research Funds of Wuhan Municipal Health Commission grant to Yan-yan Chen (Grant NO: EX20B01).

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.