Man dies in fatal house fire in Brocton... A fire that began in the basement area of a home in the village of Brocton early Christmas morning has resulted in the death of a man living there. County fire dispatchers say Brocton firefighters were called to the scene at 94 Old Mill Rd. shortly after 5 a.m. It was during the course of putting out the blaze that the deceased man's body was found inside. He has not been identified. Multiple mutual aid companies were called in to assist. Once the fire was out... the county's Fire Investigation Team was called in... and, determined the fire began in the ceiling area of the basement. The exact cause is still being determined.

One man was taken into police custody after police in Jamestown, New York said he struck another man with a shotgun. This incident happened on December 24 around 12:30 p.m. on the City of Jamestown’s north side. According to police, they initially responded to a domestic dispute. Police continued...

The liquid part of the blood, called plasma, helps waste flow to the kidney to be removed from your body through urine. There are also solid particles in the blood, including red blood cells and platelets. Red blood cells carry oxygen from your lungs to the rest of your body, including the cells of your kidney. Platelets have the job of plugging up any damaged part of the blood vessel to keep it from leaking.

TTP and HUS have different treatments. To prevent death and serious organ damage TTP requires immediate treatment with plasma exchange (PLEX) – see Figure 5 for a diagram. The process occurs as follows:

Warren County's annual Shop with A Cop program has concluded, bringing joy to hundreds of children in our community. This year, over 200 children participated, making it the largest shop with a cop event to date. “We had an absolutely great year," stated Charles Andersen, Conewango Township Police patrolman. "It...

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It is a pattern of damage that can occur in the smallest blood vessels inside many of your body’s vital organs – most commonly the kidney and brain.

There are also many less typical patterns of TTP and HUS. Doctors have not yet determined exactly why they occur, but they usually only happen to people who already have another chronic medical condition. Examples of conditions that can lead to this atypical TTP and HUS include pregnancy, organ transplant, and diseases like HIV, lupus, and cancer.

A diagnosis of TTP and HUS should be considered whenever a person comes to the hospital with several of the symptoms mentioned above. Your doctor will perform a careful physical exam and then check some blood work. The following test results raise significant concern for TTP or HUS:

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Two Chautauqua County departments will be leasing out space in Jamestown City Hall in 2025, with one agreeing to a five-year lease. The leases with the county's Health Department and Mental Hygiene Department were recently approved in committee, and Finance Committee Chairman Brent Sheldon says they're pleased they were able to get a five-year deal done with the Department of Mental Hygiene to return to the building's top floor...

A Clymer native has been named the recipient of this year's Dan Feather Memorial Award. The Chautauqua County Sheriff's Academy at Jamestown Community College recently awarded recruit Matthew White with the award, which is presented annually to a Chautauqua County resident attending the Sheriff's Academy who is noted for their professionalism and character. This year's award is $1,400. White is the 27th recipient of the Dan Feather Memorial Scholarship. He graduated from Clymer Central School in 2021 and JCC in 2023, earning an Associate's degree in criminal justice with high honors. He was accepted into the Sheriff's Academy in June. Verna Feather created the scholarship to honor her husband, the late Dan Feather, and help those beginning to pursue a career in police work.

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The spirit of giving was shining bright in Warren this week as the Bucket Brigade Pizza Company hosted their annual "Christmas Give Back" event. Over 200 free, wood-fired pizzas were prepared and served to community members, all part of the Bucket Brigade Pizza Company's annual "Christmas Give Back" day. In...

In many of the more atypical TTP/HUS disease patterns the optimal treatment has not yet been standardized. These are often treated (like TTP) with plasma exchange, but there is currently some debate about this.

(WNY News Now) – In the early hours of December 25, 2024, the Cattaraugus County Sheriff’s Office conducted an arrest on Route 219 in the Town of Great Valley. Johnnylee A. Cunningham, 24, was apprehended after deputies executed a bench warrant issued for his arrest. The warrant was...

According to reports from the Dunkirk Observer, the Portland and Brocton Fire Departments responded to a fire around 5:10 a.m. Wednesday near the 100 block of Old Mill Road in Brocton. The Chautauqua County Fire Investigation Team was called in to investigate the fire’s origin, which they determined started in the basement ceiling. After the […]

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Per New York State Agriculture and Markets Law 303-b, the Chautauqua County Legislature has designated January 2-31, 2025 as the annual 30-day period during which landowners may submit requests to include predominantly viable agricultural land into an existing certified agricultural district. During this period, landowners may submit written requests for inclusion into the Agricultural District. Parcels requesting inclusion must meet the definition of "viable agricultural land" as defined in Agriculture and Markets Law §301, subdivision 7. Lands already included in the district need not submit a request.

(WNY News Now) – A routine traffic stop in the Town of Freedom led to a significant drug seizure, uncovering meth, mushrooms, fentanyl, and other substances. On December 26, 2024, at approximately 10:18 p.m., Cattaraugus County Sheriff’s Deputies conducted a traffic stop on Route 98 near Brown School House Road. The routine stop escalated into a drug investigation resulting in the arrest of two individuals and the seizure of a large quantity of controlled substances.

This process allows the abnormal glue (vWF) that causes TTP to be exchanged for normal vWF. Treatments usually last a few hours each and continue every 1-2 days for about 2 weeks. For those with repeated episodes of TTP, a medication called rituximab is being tested to see if its use can prevent recurrences of the disease.

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TTP and HUS are quite rare. A city with a population of 1 million will average only about 11 cases in a given year. Women and blacks are somewhat more likely to develop the diseases. For unknown reasons HUS is much more common in children, and TTP is more common in adults.

Your doctor may examine the blood under a microscope to determine if there are any damaged red blood cells (known as schistocytes). Positive testing in a child who has recently had bloody diarrhea will lead to a diagnosis of HUS. Positive testing in an adult makes TTP the most likely diagnosis.

ELLERY, NY – In the early hours of December 24, a vehicle operated by Kahley Klemens, 21, of Jamestown, NY, overturned on Route 430 in the Town of Ellery. According to authorities, Klemens was traveling westbound at an unsafe speed given the icy road conditions. The vehicle lost traction,...

In contrast, HUS usually improves on its own. Patients will require hospitalization for fluids and monitoring while the disease is worsening. If kidney function declines too much, manual blood cleaning with dialysis may be necessary. As the causative bacterial infection resolves, toxin leaves the body and symptoms of HUS begin to improve.

In the normal kidney (as in the rest of the body), there are small blood vessels called capillaries. They are lined with a slippery coating of cells known as endothelial cells (see Figure 1).

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TTP was once fatal in 90% of individuals who developed the disease. Now that plasma exchange is available, survival can be as high as 80%. In many cases the blood vessel damage in the kidneys and brain will reverse with time.

JAMESTOWN, N.Y. – At Audubon Community Nature Center’s (ACNC) First Sunday Story Time, 2–8 year olds go on literary adventures with animals through habitats and seasons and discover new things with every page. On Sunday, Jan. 5, 2025, from 12:30 – 1 p.m., storyteller Claire Certo will...

UPDATE: Lehigh Valley weather: ‘Very slippery’ nighttime travel possible on icy roads, walks, bridges. Freezing rain will make roads and sidewalks slippery Friday night into Saturday, according to a winter weather advisory issued by the National Weather Service. The advisory runs from 7 p.m. Friday to 9 a.m....

HUS has a good prognosis. During the active phase of the disease kidney failure can often be severe enough to require manual blood cleaning with dialysis. Fortunately this is usually temporary. In fact kidney function almost always returns to the normal range within a few months.

A once-in-a-generation financial opportunity for Cattaraugus County is being jeopardized by inaction from the Industrial Development Agency (IDA). The IDA has yet to vote on the PILOT agreement for the Alle-Catt Wind project, which could result in millions of dollars left on the table for Cattaraugus County communities. After eight...

After a mild and overcast Friday, temperatures will climb into the low 70s inland on Saturday as high pressure shifts offshore and southerly winds develop. However, scattered light showers may dampen coastal areas as a coastal trough meanders inland. A more significant weather system will arrive Sunday into early Monday, with a strong cold front bringing widespread rain, strong winds, and the potential for severe storms.

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TMA also changes how a drop of your blood looks under a microscope. Normal blood has completely round red blood cells and plenty of tiny platelets. When you suffer from TMA your blood will have deformed red blood cells (called schistocytes) and no platelets.

ALLEGANY, NY – Kicking off the annual Joe DeCerbo Holiday Showcase, the Salamanca girls’ basketball team suffered their second loss of the season, falling to Port Allegany 57-47. Coming into this cross-state matchup, both squads were in the midst of win streaks. While the Lady Gators had strung together six straight wins, Salamanca had tallied three in a row, beating Pioneer, Springville and Franklinville by a combined 34 points.

WARREN, Pa. – A 10-hour standoff involving multiple local and state agencies ended with a Warren man in custody last weekend. According to court records, Darrel L. Martemus is facing five counts related to the incident that began in his apartment at the Allegheny Village on Dec. 20, 2024. Martemus is being held at the Warren County Jail on $75,000 bail while awaiting a preliminary hearing for Aggravated Assault (F1), Terroristic Threats (F3), Unlawful Restraint (M1), Simple Assault (M3), and Harassment (S) charges.

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In summary, your body becomes unable to keep vWF glue short enough to prevent abnormal clot and damage to the small blood vessels of your body.

UNC Kidney Center 7024 Burnett-Womack / CB # 7155 Chapel Hill, NC 27599-7155 Phone: (919) 966-2561 View Faculty & Staff Directory

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A Jamestown woman faces multiple charges following a report of unwanted subjects at a residence on the city's north side early Friday. Jamestown Police say the report, which was called in just before 2:15 AM, stemmed from an incident at the Wine Cellar in the downtown area. Officers say they were speaking with two individuals involved, when 43-year-old Mary Mowell picked up a dumbbell and charged at an officer and the two individuals. Mowell was quickly subdued by officers and taken into custody without further incident. She was transported to the Jamestown City Jail and charged with obstruction, resisting arrest and unnecessary noise. Due to New York State's bail reform law, Mowell was given an appearance ticket to appear in Jamestown City Court at a later date.

In contrast, HUS most often occurs when your body is exposed to a certain type of toxin (Figure 4). The toxin usually comes from a bacterial infection of the intestines. Generally this infection must be serious enough to cause bloody diarrhea. The toxin makes its way into the blood stream and then damages endothelial cells in the kidney. This triggers platelets to clot and red blood cells to burst as described above. For unknown reasons HUS usually occurs in children rather than adults.

There are several complex and often quite serious illnesses that can lead to TMA – these are listed in the table below. This article will discuss the first two of these: Thrombotic Thrombocytopenic Purpura and Hemolytic Uremic Syndrome. Given their complicated names, it is best to refer to these by the abbreviations TTP and HUS.

TMA causes changes in your kidney that can be seen under a microscope. The pictures below show blood vessels in the main filter of the kidney (called the glomerulus). A healthy blood vessel appears as a circle with an open (white) center. Vessels affected by TMA will be filled with a pinkish material, which is clot. Over time, parts of the kidney may die from lack of blood flow.

TTP usually occurs when platelets stick together too easily (Figure 3). Platelets use a glue in the plasma called von Willebrand Factor (vWF) to hold themselves together in the form of a clot. The glue can be more or less sticky depending on the size of its molecules – so if the glue molecules become too long, the platelets will form clots even when they’re not supposed to. Usually the body keeps vWF glue cut to exactly the right length with an enzyme called ADAMTS13. TTP develops when a shortage of that enzyme results in unwanted clotting in the small blood vessels of the kidney. The shortage can be caused by one of the following:

(WNY News Now) – The city of Lockport has declared a code blue notice for tonight, December 26th, through 8 a.m. tomorrow, December 27th. Code Blue will be in effect tonight from Thursday December 26th through tomorrow December 27th, 2024. Overnight temperatures are forecast below freezing throughout the period. Mayor Lombardi has called for Code Blue to continue through 8 am on Friday morning December 27th, 2024.

Defects in the blood vessel wall lining can produce rough patches that are like potholes on a road – they can slow traffic and cause a lot of damage. Red blood cells can become deformed and then burst. Platelets can activate and cause clots to form. The wreckage from all these events can close off entire blood vessels. In the end, parts of your kidney can die from lack of blood flow, and your body can run low on red blood cells and platelets.